Common scale-up methods are conventional where the blind　piloting is essential.　This imposes huge investment and leads to failures mostly in solid processing.　However, the limitations of resources, current shortcomings, short time-to-market demand are forced companies to minimize piloting. With these situations in mind, current digitalization outlook and computational facilities, we proposed and developed a novel iterative scale up method with case studies which highly expedites the process innovation through the following key sequences: